Amoxicillin vs Azithromycin (Z-Pack): Which Antibiotic for Your Child?

Quick Comparison: Amoxicillin vs Azithromycin

When Doctors Choose Amoxicillin (First-Line Choice)

Amoxicillin is the first choice antibiotic for most common childhood infections:

• Ear infections (otitis media) - most effective against common ear bacteria
• Strep throat - gold standard treatment
• Sinusitis - first-line for bacterial sinus infections
• Typical pneumonia - community-acquired pneumonia

When Doctors Choose Azithromycin (Z-Pack)

Azithromycin is typically used when:

• Penicillin/amoxicillin allergy - safe alternative, no cross-allergy
• Atypical pneumonia (walking pneumonia) - better coverage for Mycoplasma
• Whooping cough (pertussis) - treatment of choice
• Compliance concerns - easier 1x daily, shorter course
• Traveler's diarrhea

Frequently Asked Questions

Is amoxicillin or azithromycin stronger?

Neither is "stronger" - they work differently. Amoxicillin kills bacteria directly, while azithromycin stops bacteria from multiplying. The right antibiotic depends on the type of infection and bacteria involved.

Can my child take azithromycin if allergic to amoxicillin?

Yes! Azithromycin is a completely different antibiotic family (macrolide) than amoxicillin (penicillin). There is no cross-allergy, making it a safe alternative for children with penicillin allergies.

Can you combine amoxicillin and azithromycin?

They are not typically taken together. If one antibiotic isn't working, your doctor may switch to the other or try a different option like Augmentin.

Why does amoxicillin need to be taken 3 times a day?

Amoxicillin leaves the body quickly, so it needs to be given every 8 hours to maintain effective levels. Azithromycin stays in tissues longer, so once daily is sufficient.